Process for the production of an abuse-proofed dosage form
AssigneeGrüNenthal GmbH
InventorsELISABETH ARKENAU-MARIC, JOHANNES BARTHOLOMÄUS
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Abstract
The present invention relates to a process for the production of an abuse-proofed dosage form containing, apart from one or more active ingredients with potential for abuse and optionally physiologically acceptable auxiliary substances, at least one synthetic or natural polymer (C) with a breaking strength of at least 500 N, wherein the formulation mixture is combined with a solvent for the polymer (C) at least in quantities such that the formulation mixture is at least uniformly moistened, the at least moistened composition is optionally divided into sub-portions, dried and shaped to yield the dosage form.
Claims25
A process for the production of a solid dosage form with at least reduced potential for abuse, said dosage form exhibiting a breaking strength of at least 500 N, said process comprising:
- a) producing a formulation mixture comprising at least one active ingredient with potential for abuse (A) and at least one synthetic or natural polymer (C);
- b) moistening the mixture with at least a sufficient quantity of a solvent for the polymer (C) to uniformly moisten the mixture;
- c) optionally dividing the mixture from step b) into sub-portions;
- d) drying the sub-portion(s) from step c) or the mixture from step b);
- and
- e) shaping the dried sub-portion or mixture from step d) to yield the dosage form.
Dependencies are inferred from the claim text.