Methods and devices for separating liquid components
OwnerNicholas A. Grippi, Roberto C. Berettainventors
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Abstract
Methods and devices for preparing a solid-fibrin web are provided. One method may include drawing blood from a patient, separating plasma from the blood, contacting the plasma with a calcium-coagulation activator and concurrently coagulating and axially centrifuging the plasma to form the solid-fibrin web. The solid-fibrin web may be suitable for regenerating body tissue in a living organism. Devices used in the methods may also be provided.
Claims19
A device for use in axial centrifugation, the device comprising:
- a container configured for axial centrifugation, the container including
- a primary chamber including an anticoagulant;
- a secondary chamber containing a coagulator;
- and
- a filter separating the primary chamber from the secondary chamber, the filter substantially preventing red and white blood cells, originating from blood drawn into the primary chamber, from entering the secondary chamber under a centrifugal force of about 1000 ×G or greater, but substantially permitting plasma and platelets originating from the blood to flow into the secondary chamber under a centrifugal force of about 1000 ×G or greater.
A device for use in axial centrifugation, the device comprising:
- a container configured for axial centrifugation, the container including
- a primary chamber including a separation medium comprising at least one of a silicone gel, polyester gel, thixotropic gel and a combination thereof;
- a secondary chamber containing a coagulator;
- and
- a diaphragm separating the primary chamber from the secondary chamber, the separation medium substantially preventing fluid communication between the primary and secondary chambers prior to centrifugation, and moving during centrifugation of about 1000 ×G or greater to provide fluid communication between the primary and secondary chambers through the diaphragm.
A device for use in axial centrifugation, the device comprising:
- a container configured for axial centrifugation, the container including
- a first chamber including a separation medium comprising at least one of a silicone gel, polyester gel, thixotropic gel and a combination thereof, the first chamber having a first circumference;
- and
- a second chamber having a second circumference and containing a coagulator, the second circumference being greater than the first circumference.
Dependencies are inferred from the claim text.