Systems and methods for biological ion channel interfaces
AssigneeThe Trustees of Columbia University in the City of New York
InventorsKenneth L. Shepard, Jacob Rosenstein, Siddharth Ramakrishnan, Jared Roseman
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Abstract
Method for interfacing an integrated circuit with a biological ion channel, the integrated circuit being at least partially disposed within an electrolytic solution and including an amplifier and one or more electrodes on a surface thereof, includes forming one or more microwells proximate the one or more electrodes, applying a lipid membrane over the integrated circuit proximate the microwells, and placing a further electrode in the electrolytic solution proximate the lipid membrane on a side opposite the integrated circuit. A biological ion channel interface is also provided.
Claims20
A method for interfacing an integrated circuit with a biological ion channel, the integrated circuit being at least partially disposed within an electrolytic solution and including an amplifier and one or more electrodes on a surface thereof, comprising:
- forming one or more microwells proximate the one or more electrodes;
- applying a lipid membrane over the integrated circuit proximate the microwells;
- and
- placing a further electrode in the electrolytic solution proximate the lipid membrane on a side opposite the integrated circuit.
A biological ion channel interface comprising:
- an integrated circuit adapted to be at least partially disposed within an electrolytic solution and comprising an amplifier and one or more electrodes on a surface thereof;
- an intermediate structure having one or more microwells formed therein and adapted to be disposed in the electrolytic solution proximate the one or more electrodes;
- a lipid membrane disposed proximate the one or more microwells;
- and
- a further electrode adapted to be disposed in the electrolytic solution proximate the lipid membrane on a side opposite the integrated circuit.
A method for interfacing an integrated circuit with a biological ion channel, the integrated circuit including an amplifier and one or more electrodes on a surface thereof, comprising:
- inserting at least a first end of the integrated circuit including the one or more electrodes into a first end of a pipette containing an electrolytic solution;
- coupling a cell to a second end of the pipette;
- and
- placing an electrical lead wire on a second end of the integrated circuit.
Dependencies are inferred from the claim text.