Manifolds and methods of using them to control fluid flows
AssigneePerkinElmer Health Sciences, Inc.
InventorsAndrew Tipler, John Irion
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Abstract
Certain embodiments described herein are directed to devices that can be used to control fluid flow through one or more detectors. In some configurations, the device can be configured as a manifold that can receive a positive pressure to decouple the flow of fluid through a chromatography column from fluid flow through a detector. In certain configurations, sample flow can be accelerated into a detector cell comprising one or more filaments.
Claims21
A manifold comprising:
- a sample inlet port configured to receive effluent from a chromatography column,
- a vent port configured to permit exit of fluid in the manifold, and a make-up gas port configured to receive gas from a gas source;
- an analytical flow cell within the manifold and fluidically coupled to the sample inlet port through a first restrictor;
- a reference flow cell within the manifold and fluidically coupled to the make-up gas port through a second restrictor;
- wherein each of the analytical flow cell and the reference flow cell is fluidically coupled to the vent port to permit exit of fluid in the manifold, and wherein the manifold is configured to decouple fluid flow through the analytical flow cell and the reference flow cell from fluid flow through the chromatography column fluidically coupled to the sample inlet port of the manifold.
A manifold comprising first and second internal filament detectors within an integral housing, the manifold comprising a sample inlet port fluidically coupled to the first filament detector cell, the manifold further comprising a make-up gas port fluidically coupled to the second filament detector cell, and the manifold further comprising an exit port fluidically coupled to each of the first and second filament detector cells.
The manifold of claim 16, further comprising a third internal restrictor between the vent port and the make-up gas port, in which the third internal restrictor is fluidically coupled to each of the vent port and the make-up gas port.
21-66. (canceled)
Dependencies are inferred from the claim text.