Non-human animals having a humanized signal-regulatory protein gene
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsAndrew J. Murphy, O. Gavin Thurston, Bindu Varghese, Cagan Gurer
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Abstract
Genetically modified non-human animals and methods and compositions for making and using the same are provided, wherein the genetic modification comprises a humanization of an endogenous signal-regulatory protein gene, in particular a humanization of a SIRPα gene. Genetically modified mice are described, including mice that express a human or humanized SIRPα protein from an endogenous SIRPα locus.
Claims30
A mouse expressing a SIRPα polypeptide comprising an extracellular portion of a human SIRPα protein and an intracellular portion of a mouse SIRPα protein.
A mouse comprising a humanized SIRPα gene that comprises exons 2, 3 and 4 of a human SIRPα gene operably linked to a mouse SIRPα promoter.
An isolated mouse cell or tissue whose genome includes a humanized SIRPα gene that encodes an extracellular portion of a human SIRPα protein linked to an intracellular portion of a mouse SIRPα protein.
Dependencies are inferred from the claim text.