Method for enhancing tumor growth
AssigneeMinerva Biotechnologies Corporation
InventorCynthia BAMDAD
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Abstract
The present application discloses a method of testing for efficacy of a potential drug agent against cancerous cells in a mammal, including generating the cancer cells in a mammal; contacting the cancer cells with a potential drug agent by administering the potential drug agent to the mammal; and measuring effect of the potential drug agent on the cancer cells, wherein reduction of number of cancer cells in the mammal is indicative of efficaciousness of the potential drug agent against cancerous cells.
Claims20
A method of testing for efficacy of a potential drug agent against cancerous cells in a non-human mammal, comprising:
- (i) generating the cancer cells in the non-human mammal;
- (ii) contacting the cancer cells with a potential drug agent by administering the potential drug agent to the mammal;
- and
- (iii) measuring effect of the potential drug agent on the cancer cells, wherein reduction of number of cancer cells in the mammal is indicative of efficaciousness of the potential drug agent against cancerous cells, wherein the method comprises contacting the cancer cells with an agent that maintains stem cells in the naïve state or reverts primed stem cells to the naïve state before carrying out step (i), after carrying out step (i), or both before and after carrying out step (i).
A method for engrafting human tumors in a non-human mammal, comprising injecting or implanting human tumor cells into the mammal, the method comprising contacting the tumor cells with an agent that maintains stem cells in the naïve state or reverts primed stem cells to the naïve state before carrying out the injecting or implanting step, after carrying out the injecting or implanting step, or both before and after carrying out the injecting or implanting step.
A method of generating metastatic tumors in a non-human mammal, comprising transferring cancer cells into the mammal, wherein the method comprises contacting the cancer cells with an agent that maintains stem cells in the naïve state or reverts primed stem cells to the naïve state, before carrying out the transferring step, after carrying out the transferring step, or both before and after carrying out the transferring step.
A method of testing for efficacy of a potential drug agent against a patient's cancerous cells in a non-human mammal, comprising:
- (i) transferring the patient's cancer cells into the non-human mammal;
- (ii) contacting the cancer cells with a potential drug agent by administering the potential drug agent to the mammal;
- and
- (iii) measuring effect of the potential drug agent on the cancer cells, wherein reduction of number of the patient's cancer cells in the mammal is indicative of efficaciousness of the potential drug agent against cancerous cells, wherein the method comprises contacting the patient's cancer cells with an agent that maintains stem cells in the naïve state or reverts primed stem cells to the naïve state before carrying out step (i), after carrying out step (i), or both before and after carrying out step (i).
Dependencies are inferred from the claim text.