Method and system for patient-specific modeling of blood flow

The system of 185, wherein the computer system is configured to modify, for each of the plurality of treatment options, the three-dimensional model using a geometric modification technique.

The system of 185, wherein the computer system is configured to modify, for each of the plurality of treatment options, the three-dimensional model using a constructive solid geometry union.

The system of 185, wherein the computer system is configured to modify, for each of the plurality of treatment options, the three-dimensional model using an elastic deformation modification technique.

The system of 185, wherein the computer system is configured to modify, for each of the plurality of treatment options, the three-dimensional model based on a simulated location of an inserted stent or bypass graft.

The system of 185, wherein the computer system is configured to modify the three-dimensional model for a subset of each of the plurality of treatment options in locations that exhibit a predetermined threshold level of a blood flow characteristic.

The system of 185, wherein the computer system is configured to:

• create the reduced order model relating to a blood flow characteristic of the patient's heart or vasculature, based on the three-dimensional model;
• and
• modify the reduced order model for each possible treatment option, using a resistance value estimated to be associated with a type and location of the respective possible treatment option.

The system of 185, wherein the computer system is configured to determine resistance values associated with possible treatment options from historical data of known resistance values associated with a known dimension or geometry of previously implemented treatment options.

The system of 185, wherein the objective function is configured to maximize blood flow or minimize pressure changes in a patient's coronary vasculature.

The system of 185, wherein the three-dimensional model representing at least the portion of the patient's heart or vasculature includes at least a portion of an aorta and at least a portion of a plurality of coronary arteries emanating from the portion of the aorta.

The system of 185, wherein the patient-specific data includes imaging data provided by computer tomography or magnetic resonance imaging techniques.

The system of 185, wherein the reduced order model includes at least one lumped parameter model representing a blood flow through boundaries of the three-dimensional model.

The system of 185, wherein the at least one computer system is configured to determine the blood flow characteristic using a parameter associated with at least one of a level of hyperemia, a level of exercise, or a medication.