Spreading implement

A method of transdermal administration of a physiologically active agent from a liquid composition to a subject including:

• providing an implement having a support, and a receptacle mounted on the support, the receptacle defining a reservoir space with an open top being configured to receive a volume of the liquid composition through the open top, the receptacle including a flexible membrane forming a base and a wall, the wall being substantially perpendicular to the base and having a working surface to spread the liquid composition over a treatment surface of the subject, wherein the base has a continuous surface such that the liquid composition cannot pass through the base, wherein at least the wall is resiliently deformable when spreading the liquid composition over the treatment surface;
• applying the liquid composition to the reservoir through the open top;
• and deforming the wall of the receptacle containing the liquid composition against the treatment surface;
• and spreading the liquid composition over the treatment surface with the working surface of the wall.