Method and composition for hyperthermally treating cells

A method providing diagnosis or therapy to a to a patient in need of neurodegenerative diagnosis or therapy, the method comprising

• administering to the patient a composition comprising an anti-beta-amyloid protein targeting agent-labeled nanoparticle and/or quantum dot between 1 nm-5 nm, where the nanoparticle and/or quantum dot forms a targeting agent and/or antibody labeled nanoparticle and/or quantum dot cell and cell exosome complex,
• exposing the patient to an energy source wherein the nanoparticle and/or quantum dot responds by expanding thus generating an acoustic signal,
• measuring the acoustic signal and relating the measured signal to a temperature of the nanoparticle and/or quantum dot-cell and cell exosome complex, and
• controlling the temperature of the nanoparticle and/or quantum dot-cell and cell exosome complex from about 39° C. to about 58° C. based on the acoustic signal to hyperthermally damage the exosome and anti-beta-amyloid protein.