Process for preparation of substituted 3'-hydroazino-diphenyl-3-carboxylic acid compounds
AssigneeGlenmark Generics Ltd
InventorsBhargav Krishnaji Upadhye, Shivaji Eknath Jagadale, Mukesh Soni
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Abstract
The present invention provides a process for the preparation of substituted 3′-hydrazino-biphenyl-3-carboxylic acid compounds. The present invention further provides a process for the preparation of 3′-{N′-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-pyrazol-4-ylidene]hydrazino}-2′-hydroxybiphenyl-3-carboxylic acid, its intermediate compounds and pharmaceutically acceptable salts thereof.
Claims24
A process for the preparation of substituted 3′-hydrazino-biphenyl-3-carboxylic acid compounds of formula I and salts thereof,
- wherein R represents hydrogen (compound of formula Ia), linear or branched C1-6 alkyl (compound of formula Ib, when R is methyl), C3-8 cycloalkyl, optionally substituted benzyl, linear or branched alkylalkoxy, tetrahydrofuranyl, tetrahydropyranyl, methyloxybenzyl, trialklsilyl, acyl, or trityl;
- the process comprising:
- a) reacting a compound of formula III,
- wherein R is as defined above, X is selected from the group consisting of Cl, Br, and I, with a compound of formula IV,
- wherein R′ represents boronic acid, boronic acid ester or halogen in the presence of a metal catalyst;
- and
- (b) optionally, deprotecting the compound of formula 1.
A compound of formula III,
- wherein X and R are as defined above.
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Dependencies are inferred from the claim text.