4-substituent-2-hydroxylmorpholine-3-one and preparation method thereof

A novel compound 4-substituent-2-hydroxymorpholin-3-one of Formula I:

• wherein,
• G is selected from the group consisting of:
• (i) groups of Formula II
• wherein,
• R1, R2, and R3 are independently selected from:
• hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, C2-C6 alkynyl, substituted or unsubstituted phenyl, halo-, —CN, —CX3, —NO2, —SR6, —SOR6, —SO2R6, —(CH2)m—NR4R5, —NR4COR5, —NR4CO2R5, —CONR4R5, —COR4, —CO2R4, hydroxyl, and C1-C6 alkoxy;
• the substituents on the C1-C6 alkyl and C2-C6 alkenyl can be independently selected from:
• hydroxyl, oxo-, C1-C6 alkoxy, phenyl, —CN, —NO2, halo-, —NR4R5, —NR4COR5, —NR4CO2R5, —CONR4R5, —COR4, and —CO2R4;
• the substituents on the phenyl can be selected from:
• hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, halo-, —CN, —NO2, —CF3, —(CH2)m—NR4R5, —NR4COR5, —NR4CO2R5, —CONR4R5, —COR4, and —CO2R4;
• and R1, R2, and R3 can not be hydrogen at the same time;
• R4 and R5 are independently selected from:
• hydrogen, C1-C6 alkyl, monohydroxyl substituted C1-C6 alkyl, and phenyl;
• R6 is hydrogen or C1-C6 alkyl;
• X is selected from Cl, Br, and F;
• m is selected from 1, 2, 3 or 4;
• (ii) groups of Formula III
• wherein,
• R7, R8, and R9 are independently selected from:
• hydrogen, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, C2-C6 alkynyl, substituted or unsubstituted phenyl, halo-, —CN, —CX3, —NO2, —SR12, —SOR12, —SO2R12, —(CH2)m—NR10R11, —NR10COR11, —NR10CO2R11, —CONR10R11, —COR10, —CO2R10, hydroxyl, and C1-C6 alkoxy;
• the substituents on the C1-C6 alkyl and C2-C6 alkenyl are each independently selected from:
• hydroxyl, oxo-, C1-C6 alkoxy, phenyl, —CN, —NO2, halo-, —NR10R11, —NR10COR11, —NR10CO2R11, —CONR10R11, COR10, and —CO2R10;
• the substituents on the phenyl can be selected from:
• hydroxyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkenyl, halo-, —CN, —NO2, —CF3, —(CH2)m NR10R11, —NR10COR11, —NR10CO2R11, —CONR10R11, —COR10, and —CO2R10;
• R10 and R11 are independently selected from:
• hydrogen, C1-C6 alkyl, monohydroxyl substituted C1-C6 alkyl, and phenyl;
• R12 is hydrogen or C1-C6 alkyl;
• X is selected from Cl, Br, and F;
• m is selected from 1, 2, 3 or 4.