Chimeric il-1 receptor type i agonists and antagonists
AssigneeEleven Biotherapeutics, Inc.
InventorsThomas M. Barnes, Jinzhao Hou, Bracken M. King
Life of this patent
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Abstract
Featured herein are non-naturally occuring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains.
Claims31
1-55. (canceled)
An isolated nucleic acid comprising a sequence encoding an amino acid sequence at least 95% identical to SEQ ID NO:21.
60-70. (canceled)
The isolated nucleic acid of claim 88, further comprising a sequence encoding a hexa-histidine tag.
An isolated nucleic acid comprising a sequence encoding SEQ ID NO:21.
An isolated nucleic acid comprising a sequence at least 95% identical to SEQ ID NO:29 and encoding an amino acid sequence at least 95% identical to SEQ ID NO:21.
Dependencies are inferred from the claim text.