Compositions, methods and kits for diagnosis of lung cancer
OwnerPaul Edward Kearney, Clive Hayward +1inventors
InventorsPaul Edward Kearney, Clive Hayward, Xiao-Jun Li
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Abstract
Methods are provided for identifying biomarker proteins that exhibit differential expression in subjects with a first lung condition versus healthy subjects or subjects with a second lung condition. Also provided are compositions comprising these biomarker proteins and methods of using these biomarker proteins or panels thereof to diagnose, classify, and monitor various lung conditions. The methods and compositions provided herein may be used to diagnose or classify a subject as having lung cancer or a non-cancerous condition, and to distinguish between different types of cancer (e.g., malignant versus benign, SCLC versus NSCLC).
Claims27
A method of determining that a lung condition in a subject is cancer comprising:
- (a) assessing the expression of a plurality of proteins comprising determining the protein expression level of at least each of BGH3_HUMAN, GGH_HUMAN, LG3BP_HUMAN, PRDX1_HUMAN and TSP1_HUMAN from a biological sample obtained from the subject;
- (b) calculating a score from the protein expression of at least each of BGH3_HUMAN, GGH_HUMAN, LG3BP_HUMAN, PRDX1_HUMAN and TSP1_HUMAN from the biological sample determined in step (a);
- and
- (c) comparing the score from the biological sample to a plurality of scores obtained from a reference population, wherein the comparison provides a determination that the lung condition is cancer.
Dependencies are inferred from the claim text.