Injectable Gelling Material
AssigneeHong Kong Universit of Science and Technology
InventorsYing Chau, Yu Yu
Life of this patent
Estimating the term…
Abstract
A material is described herein. The material includes a multi-vinylsulfone containing molecule and a multi-nucleophile containing molecule. The material can form a hydrogel from an aqueous solution with dissolved multi-vinylsulfone and a multi-nucleophile. The aqueous solution can undergo gelation with a controllable gelation time to form the hydrogel upon administration to a space in a body. The hydrogel can form in situ with controllable properties, which allow the hydrogel to be used in many biomedical applications. Examples of biomedical applications include, but are not limited to, a volume/filler expander, a storage and delivery mechanism for biologics, and as a tissue interacting surface.
Claims21
A material, comprising:
- a multi-vinylsulfone containing molecule;
- and
- a multi-nucleophile containing molecule,
- wherein the material dissolves in a buffer solution to form an aqueous solution, and
- wherein the aqueous solution undergoes gelation upon administration to a space in a body with at least one of a controllable gelation time, a controllable swelling ratio, a controllable degradation time and a controllable mechanical property to facilitate filling the space.
A method, comprising:
- dissolving a multi-vinylsulfone containing molecule and a multi-nucleophile containing molecule in water to form an aqueous solution;
- injecting the aqueous solution to a space in a body;
- and
- forming a hydrogel at the space after a gelation time elapses to facilitate filling the space.
A method, comprising:
- forming an aqueous solution by dissolving a multi-vinylsulfone containing molecule and a multi-nucleophile containing molecule in water;
- administering the aqueous solution to a site in a body;
- and
- creating a biocompatible surface that interacts with the body upon administration to the site.
Dependencies are inferred from the claim text.