Antimicrobial medical devices containing chlorhexidine free base and salt
AssigneeThe Trustees of Columbia University in the City of New York
InventorsShanta M. Modak, Lester A. Sampath
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Abstract
The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.
Claims10
An antimicrobial medical article prepared by treating a hydrophobic polymeric medical article, for an effective period of time, with a solution consisting essentially of one or more solvents and a mixture of chlorhexidine free base and a water-soluble chlorhexidine salt, wherein the weight/weight ratio of chlorhexidine free base and the water-soluble chlorhexidine salt in the solution is between 1:1 to 1:5.
A method of preparing a medical article comprising the steps of:
- (i) placing the medical article in a solution consisting essentially of (a) a solvent selected from the group consisting of water, reagent alcohol, tetrahydrofuran, dimethylsulfoxide, dimethylformamide, N-methyl-2-pyrrolidone, and mixtures thereof;
- and (b) a mixture of chlorhexidine free base and a water-soluble chlorhexidine salt, wherein the weight/weight ratio of chlorhexidine free base and water-soluble chlorhexidine salt in the solution is between 1:1 to 1:5;
- (ii) soaking the medical article in the solution for an effective period of time to allow the medical article to swell;
- (iii) removing the medical article from the solution;
- and
- (iv) drying the medical article.
An antimicrobial medical article prepared by treating a medical article, for an effective period of time, with a solution comprising a solvent and an antimicrobial mixture consisting essentially of chlorhexidine free base and a water-soluble chlorhexidine salt, wherein the molar ratio of chlorhexidine free base and the water-soluble chlorhexidine salt in the solution is between 1:1 and 1:5.
Dependencies are inferred from the claim text.