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AssigneesPresident and Fellows of Harvard College, The General Hospital Corporation
InventorsBruce P. BEAN, Clifford J. WOOLF
Estimating the term…
The invention features a method for inhibiting one or more voltage-gated ion channels in a cell by contacting the cell with (i) a first compound that activates a channel-forming receptor that is present on nociceptors and/or pruriceptors; and (ii) a second compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels, wherein the second compound is capable of entering nociceptors or pruriceptors through the channel-forming receptor when the receptor is activated. The invention also features a quaternary amine derivative or other permanently or transiently charged derivative of a compound that inhibits one or more voltage-gated ion channels when applied to the internal face of the channels but does not substantially inhibit said channels when applied to the external face of the channels.
1-25. (canceled)
A method for treating pain or itch in a patient, said method comprising administering to said patient a composition comprising a compound capable of inhibiting one or more voltage-gated ion channels present in nociceptors an/or pruriceptors when applied to the internal face of said channels but does not substantially inhibit said channels when applied to the external face of said channels, wherein said compound is capable of entering nociceptors or pruriceptors through a channel-forming receptor when said receptor is activated and inhibiting said one or more voltage-gated ion channels present in said nociceptors.
Dependencies are inferred from the claim text.