Treating critically ill patients with intravenous ibuprofen
AssigneeCumberland Pharmaceuticals Inc.
InventorsLeo Pavliv, Amy Dix Rock
Life of this patent
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Abstract
Methods of treating at least one condition chosen from pain, inflammation, and fever in a critically ill patient in need thereof, comprising administering to the critically ill patient an intravenous pharmaceutical composition comprising ibuprofen using a first dosage regimen, wherein the first dosage regimen produces a first pharmacokinetic profile in critically ill patients that is about equivalent to a second pharmacokinetic profile produced by administration of the intravenous pharmaceutical composition using a second dosage regimen of ibuprofen to non-critically ill patients, wherein the at least one condition of the critically ill patient is thereby treated.
Claims21
1-23. (canceled)
A method of treating pain in critically ill patients in need thereof, comprising administering to critically ill patients an intravenous ibuprofen pharmaceutical composition using a first dosage regimen, wherein the first dosage regimen produces a first pharmacokinetic profile in critically ill patients that is about equivalent to a second pharmacokinetic profile produced by administration of the intravenous pharmaceutical composition using a second dosage regimen of ibuprofen to non-critically ill patients, wherein the critically ill patients are not suffering from inflammation and are receiving at least one treatment selected from vasopressor support, mechanical ventilation, large volumes of blood products;
- multiple antibiotics;
- have a pulmonary artery catheter or an arterial blood pressure catheter inserted;
- are being treated in an Intensive Care Unit;
- and combinations of any of the foregoing;
- and pain is thereby treated.
A method of treating pain in critically ill patients in need thereof, comprising administering to critically ill patients an intravenous ibuprofen pharmaceutical composition in a dose of about 800 mg to treat pain in said patients, wherein the critically ill patients are not suffering from inflammation and are receiving at least one treatment selected from vasopressor support, mechanical ventilation, large volumes of blood products;
- multiple antibiotics;
- have a pulmonary artery catheter or an arterial blood pressure catheter inserted;
- are being treated in an Intensive Care Unit;
- and combinations of any of the foregoing.
Dependencies are inferred from the claim text.