Protective Effects of Curcumin Against Hemorrhagic Stroke Injury
AssigneeGeorgia Regents Research Institute, Inc.
InventorsCargill H. Alleyne, JR., Krishnan M. Dhandapani, Ken Wen, MingLiang Ma, WenJing Hu
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Abstract
Disclosed herein are compounds, compositions and methods for preventing and treating diseases such as intracerebral hemorrhage, cancer, or conditions associated with damaged cells, activated lymphocytes, or microbial products. The disclosed compounds are curcumin analogs. The curcumin analogs possess anti-inflammatory and antioxidant properties, which in part, reduce AP-1 and NF-κB activity.
Claims22
A compound having the formula:
- wherein
- R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently selected from the group consisting of hydrogen, alkyl, halogen, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, alkoxydialkylamino, aminocarbonyl, alkylaminocarbonyl, dialkylamino carbonyl, haloalkyl, haloalkloxy, haloalkylamino, and di(haloalkyl)amino, and
- R11 is selected from the group consisting of hydrogen, alkyl, halogen, alkoxy, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, ester, alkyl ester, haloalkyl, haloalkloxy, haloalkylamino, and di(haloalkyl)amino.
A method for treating a disease or pathology in a subject in need thereof comprising administering a composition to the subject comprising a compound, or a pharmaceutically acceptable salt, prodrug, clathrate, tautomer or solvate thereof, wherein the compound has the structure:
- wherein
- R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 are independently selected from the group consisting of hydrogen, alkyl, halogen, alkoxy, amino, alkylamino, dialkylamino, cyano, nitro, formyl, carboxyl, alkoxycarbonyl, alkoxydialkylamino, aminocarbonyl, alkylaminocarbonyl, dialkylamino carbonyl, haloalkyl, haloalkloxy, haloalkylamino, and di(haloalkyl)amino, and
- R11 is selected from the group consisting of hydrogen, alkyl, halogen, alkoxy, amino, alkylamino, dialkylamino, carboxyl, alkoxycarbonyl, ester, alkyl ester, haloalkyl, haloalkloxy, haloalkylamino, and di(haloalkyl)amino.
Dependencies are inferred from the claim text.