Composition and method for treating neurodegenerative disease
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsCurt R. Freed, Wenbo Zhou
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Abstract
The present invention provides a method and composition for treating a neurodegenerative disease. In particular, the present invention provides a method and composition to increase DJ-1 gene expression or DJ-1 protein activity to treat a neurodegenerative disease.
Claims13
A method for treating a neurodegenerative disease in a subject, said method comprising administering to a subject in need of such a treatment a composition comprising a compound that increases DJ-1 gene expression or DJ-1 protein activity.
A method for treating a neurodegenerative disease in a subject in need of such a treatment, said method comprising increasing DJ-1 expression in said subject by administering a therapeutically effective amount of a compound that increases DJ-1 expression level by at least 150%, wherein increase in DJ-1 expression reduces the amount of neuron death.
A method for protecting dopamine neurons from a neurotoxic insult comprising administering a compound to increase DJ-1 expression in the dopamine neurons, thereby increasing survivability of said dopamine neurons.
Dependencies are inferred from the claim text.