Microrna-based methods and compositions for the diagnosis, prognosis and treatment of tumor involving chromosomal rearrangements
AssigneeUniversity of Bremen
InventorsJoern Bullerdiek, Volkhard Rippe
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Abstract
Provided are novel methods and compositions for the diagnosis, prognosis and treatment of tumor involving a chromosomal rearrangement, in particular a tumor or neoplasia of the thyroid gland. In addition, methods of identifying anti-tumor agents are described.
Claims25
A method of diagnosing whether a subject has, or is at risk for developing a tumor with a chromosomal rearrangement, the method comprising measuring the level of at least one microRNA (miR) in a test sample from the subject, wherein the presence or increased level of the miR in the test sample, relative to the level of a corresponding miR in a control sample, is indicative of the subject either having, or being at risk for developing said tumor, wherein the miR is or belongs to the C19MC or miR-371-3 cluster.
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A method for treating a subject suffering from a tumor with a chromosomal rearrangement, said method comprising administering to a subject a compound capable of inhibiting expression of at least one miR that is or belongs to the C19MC or miR-371-3 cluster.
A method of inhibiting proliferation of a cell of a tumor involving a chromosomal rearrangement comprising:
- (i) introducing into the cell one or more agents which inhibit expression or activity of one or more miRs which expression is induced or increased in the tumor cell having a chromosomal rearrangement, relative to a control cell;
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- (ii) maintaining the cell under conditions in which the one or more agents inhibits expression or activity of the miR, thereby inhibiting proliferation of the tumor cell.
A method of identifying an anti-tumor agent for a tumor, comprising providing a test agent to a cell and measuring the level of at least one miR associated with increased expression levels in tumor cells having a chromosomal rearrangement, wherein a decrease in the level of the miR in the cell, relative to a suitable control cell, is indicative of the test agent being an anti-tumor agent.
A kit for use in comprising one or more reagents for detecting one or more miRs wherein the miR is or belongs to the C19MC or miR-371-3 cluster.
Dependencies are inferred from the claim text.