Micro-rnas involved in macular degeneration
AssigneesThe Administrators of the Tulane Educational Fund, Board of Regents, The University of Texas System
InventorsShusheng Wang, Eric Olson, Qinbo Zhou
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Abstract
The present invention relates to the involvement of miR function in the development of age-related macular degeneration (AMD). It is shown that miR-23, miR-24 and/or miR-27 are involved in pathologic neovascularization in AMD, and that agonism (miR-24) and inhibition (miR23/27) of the function of these molecules blocks events contributing to development and progression of disease.
Claims25
A method of treating age-related wet macular degeneration (AMD) comprising administering to a subject (a) antagonists of miR-23 function and miR-27 function, (b) an antagonist of miR-23 function or miR-27 function and an agonist of miR-24 function, or (c) antagonists of miR-23 function and miR-27 function and an agonist of miR-24.
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A method of treating a pathologic neovascular disease state or condition comprising administering to a subject (a) antagonists of miR-23 function and miR-27 function, (b) an antagonist of miR-23 function or miR-27 function and an agonist of miR-24 function, or (c) antagonists of miR-23 function and miR-27 function and an agonist of miR-24.
Dependencies are inferred from the claim text.