Method for Treating Scleroderma
AssigneeThe Regents of the University of Colorado, a body corporate
InventorsHang Yin, John Varga, Swati Bhattacharyya
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Abstract
The present invention provides a method for treating scleroderma by administering a therapeutically effective amount of a toll like receptor 4 inhibitor to a subject in need of such a treatment.
Claims22
A method for treating scleroderma or a related autoimmune or a fibrotic condition in a subject comprising administering a therapeutically effective amount of a toll like receptor 4 inhibitor to the subject in need of such a treatment.
A method for treating scleroderma or a related autoimmune or a fibrotic condition in a subject comprising administering to the subject in need of such treatment a therapeutically effective amount of a compound of the formula:
- wherein
- each of n and m is independently an integer from 0 to 5;
- each X1 is independently alkoxide, optionally-substituted alkyl, or alkenyl;
- X2 is O, NRa, or S;
- X3 is —ORb, —SRb, or —NRbRc;
- each X4 is independently halide or alkoxide;
- and
- each of Ra, Rb, Rc, R1, R2, and R3 is independently hydrogen or alkyl.
Dependencies are inferred from the claim text.