Diamide Inhibitors of Cytochrome P450

A compound having the formula:

• wherein:
• Q is —NR5R6 or Q is —OR5 and R6 is absent;
• m is 1-3;
• at least one of the R1, R2, R3, R4, R5, and R6 groups present is C1-C6 alkyl substituted with an optionally substituted benzofuran;
• each of R1, R2, R3, R4, R5, and R6 that is present is independently is selected from the group consisting of H, optionally substituted C1-C8 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclo, optionally substituted heterocycloalkyl, and optionally substituted heterocycloalkylalkyl;
• where each optional substituent is independently selected from the group consisting of halo, —CN, —NO2, —COnR, —CON(R)2, —C(S)R, —C(S)N(R)2, —SOnN(R)2, —SR, —SOnR, —N(R)2, —N(R)COnR, —NRS(O)nR, —NRC[═N(R)]N(R)2, —N(R)N(R)COnR, —NRPOnN(R)2, —NRPOnOR, oxo, ═N—OR, ═N—N(R)2, ═NR, ═NNRC(O)N(R)2, ═NNRCOnR, ═NNRS(O)nN(R)2, ═NNRS(O)n(R)C1-C8 alkyl, —OR, alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C5-C8 cycloalkenyl, heterocyclo, aryl, and heteroaryl;
• each R is independently selected from the group consisting of:
• H, C1-C8 alkyl, C3-C5 cycloalkyl, cycloalkylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclo, heterocycloalkyl, and heterocycloalkylalkyl;
• and
• each n is independently 1 or 2;
• provided that at least two of the R1, R2, R3, R4, R5, and R6 groups present are not H;
• and
• provided that when Q is —NR5R6, R1 and R2 are isobutyl, R3 and R4 are H, and R5 is —CH2-[5]-benzofuranyl, then R6 cannot be —CH2-4-pyridyl, —CH2-1,5-dimethyl-3-pyrazole, or —CH2-4-methyl-2-thiazole.