Morphinan-derivatives for treating diabetes and related disorders

A method for treating a disease or condition, where the disease or condition is insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus, obesity, and/or diabetic nephropathy, using a morphinan-derivative comprising:

• administering, to a subject in need thereof, an effective amount of the morphinan-derivative having the general formula (I)
• wherein
• R1 is selected from —OH, —CO2H, —R0, —OR0, —OC(═O)R0, —OC(═O)OR0 or —OC(═O)NHR0;
• and
• R2 is selected from —H, —R0, —C(═O)R0, —C(═O)OR0, —C(═O)NHR0 or —C(═NH)—NH—C(═NH)—NH2;
• wherein
• R0 is in each case independently selected from —C1-C6-alkyl, -aryl, -heteroaryl, —C1-C6-alkyl-aryl or —C1-C6-alkyl-heteroaryl, in each case independently unsubstituted or substituted;
• or a physiologically acceptable salt and/or stereoisomer, including mixtures thereof in all ratios,
• where the disease or condition is selected from the group consisting of insulin-dependent diabetes mellitus, non-insulin-dependent diabetes mellitus, obesity, and/or diabetic nephropathy.