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AssigneeKemPharm, Inc.
InventorsTravis Mickle, Sven Guenther, Christal Mickle, Guochen Chi, Jaroslaw Kanski, Andrea K. Martin, Bindu Bera
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The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
1-17. (canceled)
A composition comprising acetaminophen and a conjugate, wherein the conjugate is benzoate-hydrocodone (Bz-HC) having the following structure:
A method for treating pain in an individual comprising the step of orally administering a pharmaceutically effective amount of a composition comprising acetaminophen and a conjugate, wherein the conjugate is benzoate-hydrocodone (Bz-HC) having the following structure:
A pharmaceutical kit including a specified amount of individual doses in a package containing a pharmaceutically effective amount of acetaminophen and a conjugate, wherein the conjugate is benzoate-hydrocodone (Bz-HC) having the following structure:
Dependencies are inferred from the claim text.