Substituted aminopyrimidine compounds and methods of use

A compound having Formula (I):

• or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof, wherein:
• X is (C3-C7)heterocyclyl, —(C1-C4)alkylene-(C3-C7)heterocyclyl, (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl, or —(C1-C4)alkylene-(5-10 membered heteroaryl), wherein X is optionally substituted by 1, 2, 3, 4, or 5 R1 groups;
• Y is
• wherein Y is optionally substituted by 1, 2, 3, or 4 R2 groups;
• each R1 and R2 is independently H, F, Cl, Br, CN, NO2, oxo (═O), —C(═O)Ra, —C(═O)ORa, —C(═O)NRaRb, —OC(═O)NRaRb, —OC(═O)ORa, —N(Rc)C(═O)NRaRb, —N(Rc)C(═O)ORa, —N(Rc)C(═O)Ra, —S(═O)2NRaRb, —S(═O)2Ra, —N(Rc)S(═O)2Ra, —N(Rc)—(C1-C4)alkylene-S(═O)2Ra, —(C1-C4)alkylene-C(═O)NRaRb, —(C1-C4)alkylene-N(Rc)C(═O)NRaRb, —(C1-C4)alkylene-N(Rc)C(═O)ORa, —(C1-C4)alkylene-OC(═O)NRaRb, —(C1-C4)alkylene-S(═O)2NRaRb, —(C1-C4)alkylene-N(Rc)S(═O)2Ra, ORa, NRaRb, —(C1-C4)alkylene-ORa, —(C1-C4)alkylene-NRaRb, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, —(C1-C4)alkylene-(C3-C8)cycloalkyl, (C3-C7)heterocyclyl, —(C1-C4)alkylene-(C3-C7)heterocyclyl, (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl, or —(C1-C4)alkylene-(5-10 membered heteroaryl), wherein each of the (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, —(C1-C4)alkylene-(C3-C8)cycloalkyl, (C3-C7)heterocyclyl, —(C1-C4)alkylene-(C3-C7)heterocyclyl, (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl and —(C1-C4)alkylene-(5-10 membered heteroaryl) is optionally substituted with 1, 2, 3, or 4 substitutents independently selected from F, Cl, Br, CN, ORa, NRaRb, (C1-C6)alkyl, —(C1-C4)alkylene-ORa and —(C1-C4)alkylene-NRaRb;
• each R3 and R4 is independently H, F, CN, —C(═O)Ra, —C(═O)ORa, —C(═O)NRaRb, —(C1-C4)alkylene-C(═O)NRaRb, —(C1-C4)alkylene-N(Rc)C(═O)NRaRb, —(C1-C4)alkylene-N(Rc)C(═O)ORa, —(C1-C4)alkylene-OC(═O)NRaRb, —(C1-C4)alkylene-S(═O)2NRaRb, —(C1-C4)alkylene-N(Rc)S(═O)2Rb, —(C1-C4)alkylene-ORa, —(C1-C4)alkylene-NRaRb, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, —(C1-C4)alkylene-(C3-C8)cycloalkyl, (C3-C7)heterocyclyl, —(C1-C4)alkylene-(C3-C7)heterocyclyl, (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl, or —(C1-C4)alkylene-(5-10 membered heteroaryl), wherein each of the (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, —(C1-C4)alkylene-(C3-C8)cycloalkyl, (C3-C7)heterocyclyl, —(C1-C4)alkylene-(C3-C7)heterocyclyl, (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl and —(C1-C4)alkylene-(5-10 membered heteroaryl) is optionally substituted with 1, 2, 3, or 4 substitutents independently selected from F, Cl, Br, CN, ORa, NRaRb, (C1-C6)alkyl, —(C1-C4)alkylene-ORa and —(C1-C4)alkylene-NRaRb;
• or R3 and R4, together with the carbon atom they are attached to, form an optionally substituted 3-8 membered carbocyclic or heterocyclic ring;
• and
• each Ra, Rb and Rc is independently H, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl, —(C1-C4)alkylene-(C3-C6)cycloalkyl, (C3-C6)heterocyclyl, —(C1-C4)alkylene-(C3-C6)heterocyclyl, (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl, or —(C1-C4)alkylene-(5-10 membered heteroaryl), wherein each of the (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl, —(C1-C4)alkylene-(C3-C6)cycloalkyl, (C3-C6)heterocyclyl, —(C1-C4)alkylene-(C3-C6)heterocyclyl, (C6-C10)aryl, —(C1-C4)alkylene-(C6-C10)aryl, 5-10 membered heteroaryl and —(C1-C4)alkylene-(5-10 membered heteroaryl) is optionally substituted with 1, 2, 3, or 4 substitutents independently selected from F, Cl, CN, N3, OH, NH2, (C1-C6)alkyl, (C1-C6)haloalkyl, (C1-C6)alkoxy and (C1-C6)alkylamino;
• or Ra and Rb, together with the nitrogen atom they are attached to, form an optionally substituted 3-8 membered heterocyclic ring.