Multicomponent crystalline system of voriconazole with fumaric acid
AssigneeBASF SE
InventorsAndreas Hafner, Tobias Hintermann, Fritz Blatter, Eva Roedel
Life of this patent
Estimating the term…
Abstract
A novel solid form of Voriconazole comprises the active ingredient (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol and fumaric acid. The solid composition comprising the two components shows improved properties such as water solubility, crystallization behavior and stability.
Claims14
A solid composition comprising (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol (Voriconazole) and fumaric acid in one common single phase.
A method for producing a solid application form of a medicament comprising Voriconazole, the method comprising adding Voriconazole and fumaric acid to the medicament.
(canceled)
Dependencies are inferred from the claim text.