Pyrimidine derivatives for the treatment of bacterial diseases

A compound of formula I, wherein formula I represents:

• wherein:
• Y represents:
• (ii) —CF3;
• (iii) —N(C1-6 alkyl)2 (e.g. —N(CH3)2);
• or
• (iv) C3-6 cycloalkyl (e.g. cyclopropyl);
• Nv, Nw, Nx, Ny and Nz independently represent —N═ or —C(H)═ but wherein only a maximum of three of Nv, Nw, Nx, Ny and Nz may represent —N═;
• n represents 0, 1 or 2 (but preferably represents 0);
• X1 and X2 independently represent —N— or —C(H)—;
• when X1 represents —N—, Q1 represents a direct bond, —C(O)— or —S(O)2—;
• when X1 represents —C(H)—, Q1 represents a direct bond or —N(Rz)—;
• Rz represents hydrogen or C1-6 alkyl;
• Rx represents C1-6 alkyl (optionally substituted by one or more substituents selected from ═O and A1), aryl or heteroaryl (which latter two groups are each optionally substituted by one or more substituents selected from A2 and A3, respectively);
• Ry, Ry1 and Ry2 independently represent hydrogen, halo, —CN, —OR10, —N(R11)(R12) or C1-6 alkyl (optionally substituted by one or more halo (e.g. fluoro) atoms);
• A1, A2, A3 and A4 independently represent halo, —CN, —OR10, —S(O)0-2C1-3alkyl, C1-6 alkyl (optionally substituted by one or more halo substituents), heterocycloalkyl (optionally substituted by one or more substituents selected from C1-3 alkyl and halo), aryl or heteroaryl (which latter two groups are optionally substituted by one or more substituents selected from B1 and B2, respectively);
• each R1 and R10 independently represent hydrogen, C1-6 alkyl (optionally substituted by one or more halo substituents), aryl or heteroaryl (which latter two groups are optionally substituted by one or more substituents selected from halo, C1-3 alkyl and —O—C1-3 alkyl);
• R11 and R12 independently represent hydrogen or C1-6 alkyl;
• B1 and B2 independently represent halo (e.g. chloro or fluoro), —CN, C1-6 alkyl (optionally substituted by one or more halo (e.g. fluoro) atoms), —OH or —O—C1-6 alkyl (optionally substituted by one or more halo (e.g. fluoro) atoms),
• or a pharmaceutically acceptable salt thereof, with the proviso that the compound is not: