Pyrrolidino heterocycles

A compound of formula (I)

• wherein
• A1, A2 and A3 are independently N or C, with the proviso that A1, A2 and A3 are not simultaneously N,
• B is C1-C4-alkylene, C2-C4-alkenylene, —O—C1-C4 alkyl or —NH—C1-C4alkyl
• R1 and R2, are independently selected from hydrogen, C1-C7-alkyl, C1-C7-hydroxyalkyl, C3-C8-cycloalkyl, R1 and R2 together with the nitrogen atom to which they are attached, form a heterocycloalkyl which can be substituted by 1 to 3 substituents independently selected from the group consisting of halogen, C1-C7-alkyl, C1-C7-hydroxyalkyl, C1-C7 alkoxy, C1-C7-haloalkyl, hydroxyl and oxo;
• R3 is selected from heteroaryl optionally substituted by 1 to 3 substituents selected from halogen, C1-C7-alkyl, cycloalkyl, C1-C7 alkoxy, C1-C7-haloalkyl, aryl, heteroaryl, —NR5R6, —O—R7, —C(O)—NR′R″, wherein heteroaryl contains at least one nitrogen atom which is adjacent to the connecting ring carbon atom,
• R4 is selected from hydrogen, C1-C7-alkyl, C3-C8-cycloalkyl,
• R5 and R6 are independently selected from hydrogen, C1-C7-alkyl, R5 and R6 together with the nitrogen atom to which they are attached, form a heterocycloalkyl which can be substituted by 1 to 3 substituents independently selected from the group consisting of halogen, C1-C7-alkyl, C1-C7-hydroxyalkyl, C1-C7 alkoxy, C1-C7-haloalkyl and oxo;
• R7 is selected from C1-C7-alkyl, C1-C7-haloalkyl and heterocycloalkyl,
• R′ and R″ are independently selected from hydrogen and C1-C7-alkyl.