Cyclic amine derivatives as ep4 receptor antagonists

A cyclic amine compound of Formula (I):

• or a pharmaceutically acceptable salt or derivative thereof, wherein:
• A is selected from the group consisting of
• wherein
• n=0, 1 or 2
• m=0 or 1
• R1 and R2 are independently hydrogen, linear or branched C1-3 alkyl or are joined together to form a cyclopropyl ring;
• R3 is H or linear or branched C1-3 alkyl
• R4 and R5 are independently hydrogen, fluorine, linear or branched C1-3 alkyl or are joined together to form a cyclopropyl ring,
• Ar is
• phenyl having:
• i. in 4-position one substituent selected from the group consisting of halogen, cyano, trifluoromethyl, or
• ii. in 3-position one substituent selected from the group consisting of halogen, cyano, trifluoromethyl, provided that
• ii.a. when A is B, both R4 and R5 are fluorine, linear or branched C1-3 alkyl or joined together they form a cyclopropyl ring,
• ii.b. A is C and m is 0
• ii.c. A is D and m is 1,
• a 5-membered heteroaromatic ring containing 1 to 3 heteroatoms wherein said heteroatoms independently of each others are S, O or N;
• or
• a 6-membered heteroaromatic ring containing 1 to 3 N.