Method for producing an aqueous dispersion of drug nanoparticles and use thereof
AssigneeOsaka University
InventorsKoichi Baba, Kohji Nishida, Noriyasu Hashida
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Abstract
A nanoparticle aqueous dispersion in which nanoparticles are dispersed in water is produced through a method including a step of freeze-drying a frozen sample of a liquid mixture of a first solution and a second solution and a step of dispersing the freeze-dried sample in water. In this method, the liquid mixture contains an active ingredient and an ointment base, the first solution includes contains an organic solvent as its solvent, and the second solution contains water as its solvent. The method, which is arranged as such, can provide an aqueous composition containing nanoparticles dispersed therein and usable stably as an aqueous dispersion preparation.
Claims15
A method for producing an aqueous dispersion in which nanoparticles including an active ingredient of a pharmaceutical drug are dispersed,
- the method comprising the steps of:
- (a) freeze-drying a frozen sample of a liquid mixture of (i) a first solution including an organic solvent as a solvent thereof, the first solution containing a pharmaceutical drug and an ointment base, and (ii) a second solution including water as a solvent thereof,
- the pharmaceutical drug being not in a form of nanoparticles,
- the liquid mixture containing no nanoparticles;
- and
- (b) dispersing the freeze-dried sample in water.
Dependencies are inferred from the claim text.