Inhibition of Opioid Antinociceptive Tolerance and Withdrawal in Nociceptive Pain Therapy
AssigneeSaint Louis University
InventorDaniela SALVEMINI
Life of this patent
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Abstract
The invention provides methods and compositions for inhibiting opioid tolerance by administering an A3AR agonist to a subject receiving opiate therapy for nociceptive pain. Also provided are methods of treating opiate withdrawal using an A3AR agonist.
Claims24
A method of reducing opioid antinociceptive tolerance in a subject receiving opiate therapy for acute/severe and chronic neuropathic (malignant and non malignant) pain comprising administering to said subject an amount of an A3AR agonist sufficient to reduce opioid antinociceptive tolerance.
11-14. (canceled)
A method of preventing or treating opioid withdrawal in a subject receiving opiates comprising administering to said subject an amount of an A3AR agonist sufficient to treat one or more symptoms of opioid withdrawal.
23-40. (canceled)
Dependencies are inferred from the claim text.