Microrna compositions and methods
AssigneesRegulus Therapeutics Inc., Alnylam Pharmaceuticals, Inc.
InventorsEric G. Marcusson, Balkrishen Bhat, Peter Linsley, Akin Akinc
Life of this patent
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Abstract
Provided herein are compositions comprising oligomeric compounds. In certain embodiments, the oligomeric compounds are useful as miRNA mimics. The oligomeric compounds may mimic the activity of miR-34. Also provided herein are methods for the treatment of cancer.
Claims35
A method of treating cancer comprising administering to a subject having cancer a composition comprising an oligomeric compound comprising an oligonucleotide consisting of 7 to 30 linked nucleosides, wherein the nucleobase sequence of the oligonucleotide has at least 80% seed region identity with the nucleobase sequence of miR-34.
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A method of regulating seed-matched transcripts comprising contacting a cell with a composition comprising an oligomeric compound comprising an oligonucleotide consisting of 7 to 30 linked nucleosides, wherein the nucleobase sequence of the oligonucleotide has at least 80% seed region identity with the nucleobase sequence of miR-34.
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A composition comprising oligomeric compound comprising an oligonucleotide consisting of 7 to 30 linked nucleosides, wherein the nucleobase sequence of the oligonucleotide has at least 80% seed region identity with the nucleobase sequence of miR-34.
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Dependencies are inferred from the claim text.