Anti-fatty acid synthase polypeptide and use thereof
AssigneeTianjin TOPTECH Bio-Science & Technology Co., Ltd.
InventorsXiaodong Zhang, Lihong Ye
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Abstract
The present invention relates to a polypeptide that is capable of inhibiting transcription and expression of fatty acid synthase (FAS) and the polynucleotides encoding therefor, as well as the use thereof. Specifically, the present invention relates to a polypeptide that can inhibit the transcription and expression of FAS at the molecular level, the cellular level and in vivo, and can therefore prevent the overexpression of FAS. Said polypeptide and related peptidomimetics, including functional fragments or functional varieties thereof, and the genes encoding therefor, can be widely used in preventing and treating tumors such as liver cancer, and diseases closely related to the metabolism of fatty acid synthase, such as fatty liver and obesity.
Claims17
An isolated polypeptide or peptidomimetic, comprising amino acid sequence as shown in SEQ ID NO:
- 1, or functional fragment or variant thereof, said polypeptide or peptidomimetic having an effect of inhibiting anti-fatty acid synthase and the occurrence and development of tumors, fatty liver and obesity.
An isolated polynucleotide, said polynucleotide is selected from the group consisting of:
- a) the polynucleotide encoding the amino acid sequence as shown in SEQ ID NO:
- 1 or the functional fragment or functional variant thereof;
- and
- b) a polynucleotide that is complementary to the polynucleotide of a) or that is capable of hybridizing with the polynucleotide of a) under stringent condition.
Dependencies are inferred from the claim text.