Diaspirin crosslinked pegylated hemoglobin
AssigneeSangart, Inc.
InventorsKim D. Vandegriff, Ashok Malavalli, Scott D. Olsen
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Abstract
PEGylated diaspirin-crosslinked hemoglobin conjugates having high oxygen affinity are described which have enhanced nitrite reductase activity to deliver oxygen, carbon monoxide, nitric oxide or mixtures thereof to tissues to treat various diseases and conditions.
Claims69
A β,β-intramolecularly-crosslinked polyoxyalkylene oxide hemoglobin conjugate having a P50 ranging from about 2 to 5 mmHg as measured at 37° C. and pH 7.4, wherein the hemoglobin conjugate when fully deoxygenated at 25° C. exhibits a maximal nitrite reductase activity that is at least 10-fold greater than that of deoxygenated stroma-free hemoglobin when measured under the same conditions.
A β,β-intramolecularly-crosslinked polyoxyalkylene oxide (PAO) hemoglobin conjugate having a P50 ranging from about 2.0 to 5.0 mmHg as measured at 37° C. and pH 7.4, the hemoglobin conjugate having a maximal nitrite reductase activity of at least 0.25 μM/sec when fully deoxygenated at 25° C.
Dependencies are inferred from the claim text.