Genes and proteins associated with angiogenesis and uses thereof
AssigneeNational Jewish Health
InventorsWilliam P. Schiemann, Allan R. Albig
Life of this patent
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Abstract
Disclosed is a panel of biomarkers associated with angiogenesis, and the use of such biomarkers (genes, proteins, homologues and analogs thereof) to regulate angiogenesis. Methods for identifying compounds useful for regulating angiogenesis and conditions related thereto are disclosed.
Claims21
1-43. (canceled)
A method to regulate angiogenesis in cells or a tissue of a patient, comprising regulating the expression or biological activity of Lumican in the cells or tissue.
A method to reduce tumorigenicity in a patient, comprising regulating the expression or biological activity of Lumican.
A method for assessing the presence of tumor cells or potential therefore in a patient, comprising:
- a) detecting a level of expression or activity of the expression or activity of Lumican in a test sample from a patient to be diagnosed;
- and
- b) comparing the level of expression or activity of Lumican in the test sample to a baseline level of Lumican expression or activity established from a control sample;
- wherein detection of a statistically significant difference in the Lumican expression or activity in the test sample, as compared to the baseline level of Lumican expression or biological activity, is an indicator of the presence of tumor cells or the potential therefore in the test sample as compared to cells in the control sample.
An assay kit for assessing angiogenesis or the presence of tumor cells in a patient, comprising:
- a) a reagent for detecting the expression or activity of Lumican in a test sample;
- and
- b) a reagent for detecting a control marker characteristic of a cell or tissue type that is in the test sample or that is secreted into the test sample by the cell or tissue.
Dependencies are inferred from the claim text.