Diacylglycerol acyltransferase 2 inhibitors

A compound of Formula (I)

• wherein:
• A is CR6R7, O or S;
• B is a bond, oxetanyl,
• wherein
• m is 0, 1 or 2;
• p is 1, 2, 3 or 4;
• C and D are each individually selected from N, CH, CF and C(CH3), wherein only one of C and
• D is N;
• R1 is —C(O)-heterocyclyl, —C(O)—NR4R5, or a heteroaryl, wherein said heterocyclyl or heteroaryl is optionally substituted with 1 or 2 substituents selected independently from (C1-C4)alkyl, (C3-C6)cycloalkyl, (C1-C4)alkoxy, (C3-C6)cycloalkoxy, halo, hydroxy(C1-C4)alkyl, mono-N— or di-N,N—(C1-C4)alkylamino, mono-N— or di-N,N—(C3-C6)cycloalkylamino, heterocyclyl, hydroxyl and cyano;
• R2 is (C1-C4)alkyl, (C1-C4)alkoxy, (C3-C6)cycloalkyl, (C3-C6)cycloalkoxy, aryl, aryloxy, heteroaryloxy, heteroaryl, heterocyclyl, aralkyl, heteroaralkyl, —C(O)-heterocyclyl, —C(O)—NR4R5, or —NR4—C(O)—R5, wherein alkyl, alkoxy, cycloalkyl, cycloalkoxy, aralkyl, heteroaralkyl, aryl, aryloxy, heteroaryloxy, heteroaryl, heterocyclyl are each optionally substituted with one, two or three substituents selected independently from (C1-C4)alkyl, (C1-C4)alkoxy, (C3-C6)cycloalkyl, (C3-C6)cycloalkoxy, —C(O)—(C1-C4)alkyl, —C(O)—(O3—C6)cycloalkyl, halo, —C(O)—(C1-C4)alkoxy, —C(O)—(C3-C6)cycloalkoxy, mono-N— or di-N,N—(C1-C4)alkylamino, mono-N— or di-N,N—(C3-C6)cycloalkylamino, (C1-C4)alkylcarbonylamino, (C3-C6)cycloalkylcarbonylamino, (C1-C4)alkylcarbonyl-N—(C1-C4)alkylamino, (C1-C4)alkylcarbonyl-N—(C3-C6)cycloalkylamino, (C3-C6)cycloalkylcarbonyl-N—(C1-C4)alkylamino, (C3-C6)cycloalkylcarbonyl-N—(C3-C6)cycloalkylamino, aminocarbonyl, mono-N— or di-N,N—(C1-C4)alkylaminocarbonyl, mono-N— or di-N,N—(C3-C6)cycloaminocarbonyl, mono-N— or di-N,N—(C1-C4)alkylcarbonyl, mono-N— or di-N,N—(C3-C6)cycloalkylcarbonyl, mono-N— or di-N,N—(C1-C4)alkoxycarbonyl, mono-N— or di-N,N—(C3-C6)cycloalkoxycarbonyl, (C1-C4)alkylthio, (C3-C6)cycloalkylthio, aminosulfonyl, (C1-C4)alkylsulfinyl, (C1-C4)alkylsulfonyl, (C3-C6)cycloalkylsulfinyl, (C3-C6)cycloalkylsulfonyl, mono-N— or di-N,N—(C1-C4)alkylaminosulfonyl, mono-N— or di-N,N—(C3-C6)cycloalkylaminosulfonyl, (C1-C4)alkylsulfonylamino, (C3-C6)cycloalkylsulfonylamino, (C1-C4)alkylsulfonyl-N—(C1-C4)alkylamino, (C1-C4)alkylsulfonyl-N—(C3-C6)cycloalkylamino, (C3-C6)cycloalkylsulfonyl-N—(C1-C4)alkylamino, (C3-C6)cycloalkylsulfonyl-N—(C3-C6)cycloalkylamino, aryl, heteroaryl, heterocyclyl, oxo, carboxyl, amino, hydroxyl and cyano, wherein said alkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, alkoxy and cycloalkoxy are optionally substituted independently with one to nine fluoro, or 1, 2 or 3 substituents selected from halo, —C(O)—OH, —C(O)—(C1-C4)alkoxy, aminocarbonyl, mono-N— or di-N,N—(C1-C4)alkylcarbonyl, mono-N— or di-N,N—(O3—C6)cycloalkylcarbonyl, cyano, amino and hydroxyl;
• R3 is (C1-C4)alkyl, (C3-C6)cycloalkyl, hydroxyl or fluoro, wherein said alkyl is optionally substituted with one to nine fluoros and said (C3-C6)cycloalkyl is optionally substituted with one to six fluoros;
• R4 and R5 are each independently selected from hydrogen, (C1-C4)alkyl, (C3-C6)cycloalkyl, aryl, heteroaryl, aryloxy, heteroaryloxy, aralkyl, heteroaralkyl, heterocyclyl, (C1-C4)alkoxy, and (C3-C6)cycloalkoxy, wherein R4 and R5 are each optionally substituted with (C1-C4)alkyl, (C1-C4)alkoxy, (C3-C6)cycloalkyl, (C3-C6)cycloalkoxy, halo or cyano, wherein each of said alkyl, cycloalkyl, alkoxy or cycloalkoxy is optionally substituted with one to nine fluoros;
• R6 and R7 are each independently hydrogen, (C1-C4)alkyl, fluoro, (C1-C4)alkoxy, hydroxyl or cyano, wherein said alkyl is optionally substituted with one to nine fluoros;
• R8 is selected from fluoro, methyl or trifluoromethyl;
• R9 and R19 are each independently selected from hydrogen, fluoro, (C1-C4)alkyl, (C3-C6)cycloalkyl, aryl or heteroaryl, wherein said alkyl is optionally substituted with one to nine fluoros, and said cycloalkyl is optionally substituted with one to six fluoros, and said aryl and heteroaryl are optionally substituted with 1, 2 or 3 substituents independently selected from fluoro, chloro, methyl, ethyl, isopropyl, cyclopropyl, methylthio, methoxy, cyano, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy, oxo and trifluoromethylthio;
• and
• n is 0, 1 or 2;
• or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.