Dosing regimens for echinocandin class compounds
AssigneeCidara Therapeutics, Inc.
InventorsBalasingam Radhakrishnan, Kenneth Duke James, JR., Anuradha Vaidya, Karen Polowy
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Abstract
The invention features pharmaceutical compositions, methods, and kits featuring dosing gimens and oral dosage formulations for administration of echinocandin class compounds.
Claims71
A method of treating a fungal infection in a subject, said method comprising (i) administering a loading-dose of an echinocandin class compound to said subject;
- and (ii) administering orally or subcutaneously one or more maintenance doses of said echinocandin class compound to said subject, wherein each of said loading-dose and said maintenance doses are administered in an amount that together are sufficient to treat said fungal infection.
A pharmaceutical composition in unit dosage form comprising:
- (a) an echinocandin class compound, or a pharmaceutically acceptable salt thereof;
- and
- (b) from 0.5% to 90% (w/w) of an additive,
- wherein said additive is present in an amount sufficient to increase the oral bioavailability of said echinocandin class compound, or salt thereof.
A method of treating a fungal infection in a subject, said method comprising subcutaneously administering to said subject an aqueous solution comprising compound 22, or a pharmaceutically acceptable salt thereof, in an amount that is sufficient to treat said fungal infection.
A device for injecting an aqueous solution of compound 22, or a pharmaceutically acceptable salt thereof, into a subject, comprising a container holding from 0.05 mL to 10 mL of said aqueous solution comprising compound 22, or a pharmaceutically acceptable salt thereof, and a needle.
A method of treating a fungal infection in a subject, said method comprising administering to said subject an intravenous bolus of an aqueous solution comprising compound 22, or a pharmaceutically acceptable salt thereof, in an amount that is sufficient to treat said fungal infection.
A method of treating a fungal infection in a subject in need thereof, said method comprising administering to said subject an intravenous infusion of an aqueous solution comprising compound 22, or a pharmaceutically acceptable salt thereof, in an amount that is sufficient to treat or prevent said fungal infection.
A pharmaceutical composition in unit dosage form comprising from 25 mL to 500 mL of an aqueous solution comprising from 0.50 mg/mL to 3 mg/mL compound 22, or a pharmaceutically acceptable salt thereof, wherein said unit dosage form is suitable for intravenous infusion into a subject.
A pharmaceutical composition in unit dosage form comprising from 1 mL to 10 mL of an aqueous solution comprising from 25 mg/mL to 500 mg/mL compound 22, or a pharmaceutically acceptable salt thereof, wherein said unit dosage form is suitable for intravenous bolus injection into a subject.
A pharmaceutical composition in unit dosage form comprising from 0.05 mL to 1.0 mL of an aqueous solution comprising from 100 mg/mL to 250 mg/mL compound 22, or a pharmaceutically acceptable salt thereof, wherein said unit dosage form is suitable for subcutaneous injection into a subject.
A kit comprising (i) a unit dosage form containing a lyophilized powder comprising compound 22, or pharmaceutically acceptable salt thereof, and (ii) instructions for reconstituting the lyophilized powder with an aqueous solution to form a pharmaceutical composition suitable for injection into a subject.
A kit comprising (i) a unit dosage form containing a liquid concentrate comprising compound 22, or pharmaceutically acceptable salt thereof, and (ii) instructions for reconstituting the liquid concentrate with an aqueous solution to form a pharmaceutical composition suitable for injection into a subject.
Dependencies are inferred from the claim text.