Antimicrobial peptides
AssigneeRobert Bosch Gensellschaft FüR Medizinische Forschung Mbh
InventorsEduard Stange, Bjoern Schroeder, Jan Wehkamp
Life of this patent
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Abstract
A novel antimicrobial peptide includes at least eight successive amino acids, the peptide exhibiting a sequence having the following formula: Ter1-X1-B1-X2-B2-X3-Z1-Z2-X4-Ter2. The peptide can moreover also have modified termini. The peptide is believed to be effective for the treatment or prevention of inflammatory and infectious diseases that are caused by microorganisms such as bacteria or fungi.
Claims16
1-12. (canceled)
A peptide or derivative thereof that has antimicrobial activity and has a C-terminus and an N-terminus, and that is made up of at least eight and at most 12 successive amino acids, the peptide exhibiting the sequence having the following formula I:
- Ter1-X1-B1-X2-B2-X3-Z1-Z2-X4-Ter2 (formula I)
- in which
- Ter1 is the free N-terminal amino group of the N-terminal amino acid X1, or a modified N-terminal amino group;
- X1, X2, and X3 are each identical or different and are selected, mutually independently in each case, from an amino acid having a basic side chain;
- B1 and B2 are identical or different and are each an amino acid having an aliphatic or basic side chain;
- Z1 and Z2 either are each cysteine, or are cysteine and alanine;
- and
- Ter2 is the free C-terminal carboxyl group of the C-terminal amino acid X4, or is a modified C-terminal carboxyl group.
A pharmaceutical composition, comprising:
- a pharmaceutically acceptable carrier;
- and
- at least one peptide or derivative thereof that has antimicrobial activity and has a C-terminus and an N-terminus, and that is made up of at least eight and at most 12 successive amino acids, the peptide exhibiting the sequence having the following formula I:
- Ter1-X1-B1-X2-B2-X3-Z1-Z2-X4-Ter2 (formula I)
- in which
- Ter1 is the free N-terminal amino group of the N-terminal amino acid X1, or a modified N-terminal amino group;
- X1, X2, and X3 are each identical or different and are selected, mutually independently in each case, from an amino acid having a basic side chain;
- B1 and B2 are identical or different and are each an amino acid having an aliphatic or basic side chain;
- Z1 and Z2 either are each cysteine, or are cysteine and alanine;
- and
- Ter2 is the free C-terminal carboxyl group of the C-terminal amino acid X4, or is a modified C-terminal carboxyl group.
A polynucleotide coding for at least one peptide or derivative thereof that has antimicrobial activity and has a C-terminus and an N-terminus, and that is made up of at least eight and at most 12 successive amino acids, the peptide exhibiting the sequence having the following formula I:
- Ter1-X1-B1-X2-B2-X3-Z1-Z2-X4-Ter2 (formula I)
- in which
- Ter1 is the free N-terminal amino group of the N-terminal amino acid X1, or a modified N-terminal amino group;
- X1, X2, and X3 are each identical or different and are selected, mutually independently in each case, from an amino acid having a basic side chain;
- B1 and B2 are identical or different and are each an amino acid having an aliphatic or basic side chain;
- Z1 and Z2 either are each cysteine, or are cysteine and alanine;
- and
- Ter2 is the free C-terminal carboxyl group of the C-terminal amino acid X4, or is a modified C-terminal carboxyl group.
Dependencies are inferred from the claim text.