Whole Blood Analytic Device And Method Therefor
AssigneeQualigen, Inc.
InventorMichael Poirier
Life of this patent
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Abstract
Devices and methods are presented in which a plasma separation device with a first and second portion separates a blood containing fluid. Most preferably, the first portion produces a cell fraction and a plasma fraction, and the second portion captures the plasma fraction. A first actuator then fluidly isolates a portion of the plasma fraction within the second portion, and a second actuator moves the isolated portion of the plasma fraction from the second portion.
Claims20
An analytic device, comprising:
- a sample receiving compartment;
- a plasma separation device that is at least partially disposed in the sample receiving compartment and comprises (1) a first portion configured to separate blood into a cell fraction and a plasma fraction, and (2) a second portion configured to capture at least a portion of the plasma fraction;
- wherein the analytic device has a first area that, when compressed by a first actuator, restricts flow of the plasma fraction between the first and the second portion;
- and
- wherein the analytic device has a second area that, when compressed by a second actuator, causes flow of a metered volume of the plasma fraction into at least one of the sample receiving compartment and a second compartment.
A method of manipulating a sample for a diagnostic test, comprising:
- contacting a plasma separation device with a blood-containing fluid, wherein the plasma separation device has a first portion and a second portion;
- using the first portion to separate the blood-containing fluid into a cell fraction and a plasma fraction, and using the second portion to capture the plasma fraction;
- using a first actuator to fluidly isolate a portion of the plasma fraction within the second portion;
- and
- using a second actuator to move the isolated portion of the plasma fraction from the second portion.
A method of manipulating a sample for a diagnostic test, comprising:
- using capillary force in a plasma separation device to separate a blood-containing fluid into a cell fraction and a plasma fraction;
- receiving and retaining at least some of the plasma fraction in a compressible membrane;
- compressing a first portion of the compressible membrane to thereby fluidly isolate a portion of the plasma fraction within the compressible membrane;
- and
- compressing a second portion of the compressible membrane while maintaining compression of the first portion to thereby dispense a predetermined volume of the plasma fraction from the compressible membrane.
Dependencies are inferred from the claim text.