S-nitrosothiol-generating skin dressings
AssigneeInsense Limited
InventorsJan Jezek, Lynne Patricia Watson
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Abstract
The present disclosure relates to a skin dressing adapted, on activation, to generate one or more S-nitrosothiols by reaction between a thiol and a nitrite salt in the skin dressing for delivery of nitric oxide to a body site. The skin dressing comprises a source of Cu2+, Zn2+ and/or Fe2+ ions.
Claims20
A skin dressing adapted, on activation, to generate one or more S-nitrosothiols by reaction between a thiol and a nitrite salt in the skin dressing, the skin dressing comprising:
- a first component comprising the nitrite salt and a buffer with a pKa of from 4.5 to 7.0;
- a second component comprising the thiol, wherein the second component is kept apart from the first component until activation;
- and
- a source of Cu2+, Zn2+ and/or Fe2+ ions.
A skin dressing comprising:
- a first component including a nitrite salt;
- a second component including a thiol;
- and
- a source of Cu2+, Zn2+ and/or Fe2+ ions;
- wherein the skin dressing has a storage state in which the first component and the second component are separated, and an activated state in which the first component and the second component contact one another;
- and
- wherein the skin dressing is adapted, in the activated state, to generate one or more S-nitrosothiols by reaction between the nitrite salt of the first component and the thiol of the second component.
A method of treating a skin wound with a skin dressing comprising a first component including a nitrite salt, a second component including a thiol, and a source of Cu2+, Zn2+ and/or Fe2+ ions, the method comprising:
- applying the first component of the skin dressing to a wound site;
- contacting the second component of the skin dressing with the first component;
- and
- generating one or more S-nitrosothiols by reacting the nitrite salt of the first component and the thiol of the second component in the presence of the source of Cu2+, Zn2+ and/or Fe2+ ions.
Dependencies are inferred from the claim text.