Nanoparticulate megestrol formulations

A method of increasing the body mass in a human patient suffering from anorexia, cachexia, or loss of body mass, comprising administering to the human patient a megestrol formulation, wherein:

• (a) the megestrol acetate formulation is a dose of about 40 mg to about 800 mg in about a 5 mL dose of an oral suspension;
• (b) the megestrol acetate formulation comprises megestrol particles, wherein about 80% of the particles are between or equivalent to about 250 nm and about 50 nm, and at least one surface stabilizer is associated with the surface of the megestrol particles;
• and
• (c) the administration is once daily;
• wherein after a single administration in a human subject of the formulation the difference in the Cmax of the megestrol when administered in a fed versus a fasted state is less than about 100%,
• wherein fasted state is defined as the subject having no food within at least the previous 10 hours, and
• wherein fed state is defined as the subject having a high-calorie meal within approximately 30 minutes of dosing.