Multi-Functional Micro and Nanoparticles for Use in Root Canal Therapies
AssigneeThe Governing Council of the University of Toronto
InventorsAnil Kishen, Annie Shrestha
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Abstract
Chitosan nanoparticles are provided for use in the in vivo treatment of connective tissues in root canal therapies. The nanoparticles are optionally linked with one or more photoactivatable compounds for providing antibactenal/antibiofilm properties, neutralizing bacterial byproducts and/or chemical/photodynamic crosslinking to achieve enhanced mechanical properties, chemical stability in connective tissues and/or to improve surface/interfacial integrity between filling material and connective tissue.
Claims31
A composition for use in in vivo disinfection and/or remineralization treatment of connective or hard tissues comprising multifunctional bioactive nanoparticles,
- said nanoparticles comprising a polysaccharide having a plurality of five or six membered ring carbohydrate monomers, where each said monomer is optionally substituted with at least one of a primary amine and a secondary or tertiary amine having an acyl group with two to seven carbon atoms.
A method of making a medicament for in vivo disinfection and remineralization of hard or connective tissues, comprising:
- forming phosphorylated chitosan polymer;
- and
- micronizing said phosphorylated chitosan polymer to form nanoparticles having an average size selected at between about 40 microns and about 80 microns, and admixing said nanoparticles with a pharmaceutically acceptable carrier.
A method of making a medicament for in vivo disinfection and remineralization of hard or connective tissues, comprising:
- forming phosphorylated chitosan polymer;
- and
- micronizing said phosphorylated chitosan polymer to form nanoparticles having an average size selected at up to about 100 nanometers, and preferably between about 60 nanometers and 90 nanometers, and admixing or mixing said nanoparticles with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.