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US 2015/0086629 A1Published application
Stabilized formulations of cns compounds
AssigneeSupernus Pharmaceuticals, Inc.
InventorsRong-Kun Chang, Michael L. Vieira, Likan LIANG, Padmanabh P. BHATT, Austin B. HUANG, Sachin V. PATEL
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Abstract
Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone.
Claims36
1-44. (canceled)
A pharmaceutical formulation comprising molindone as a single active pharmaceutical ingredient and having:
- (a) a modified-release formulation comprising:
- (i) at least one release controlling polymer selected from the group consisting of pH-dependent polymers and non-pH-dependent polymers, and
- (ii) at least one stabilizer selected from the group consisting of acidifying agents and hydrophobizing agents;
- and, optionally,
- (b) an additional formulation comprising molindone in an immediate release, extended release, or delayed release formulation.
2 more elements
Dependencies are inferred from the claim text.