Antiretroviral composition
OwnerShrinivas Madhukar Purandare, Geena Malhotrainventors
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Abstract
The present invention provides a pharmaceutical solid oral sprinkle composition comprising one or more antiretroviral drugs, and a method of manufacturing the same. The present invention is particularly useful for treatment of an HIV infection, AIDS related complex, or AIDS.
Claims43
A pharmaceutical solid oral sprinkle composition, comprising a plurality of particles, the plurality of particles comprising a first and a second antiretroviral drug and at least one polymer, wherein the first antiretroviral drug comprises ritonavir.
A pharmaceutical solid oral sprinkle composition comprising ritonavir and lopinavir;
- and at least one polymer comprising:
- a water soluble polymer;
- a water swellable polymer;
- a water insoluble polymer;
- or any combination thereof.
A process for preparing a pharmaceutical solid oral sprinkle composition which is a sprinkle formulation comprising a plurality of particles, the plurality of particles comprising a first and a second antiretroviral drug, wherein the first antiretroviral drug comprises ritonavir, the process comprising:
- (a) melt granulating one or more solubility enhancers and one or more pharmaceutically acceptable excipients with the or each drugs in purified water to form a granulated material;
- (b) sieving the granulated material;
- (c) drying the sieved granulated material to form dried granules;
- (d) lubricating the dried granules with one or more lubricants and one or more second pharmaceutically acceptable excipients;
- and
- (e) optionally further processing the lubricated dried granules to provide the dosage form.
43-44. (canceled)
Dependencies are inferred from the claim text.