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US 2015/0086614 A1Published application
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
AssigneeModerna Therapeutics, Inc.
InventorsStephane Bancel, Tirtha Chakraborty, Antonin de Fougerolles, Sayda M. Elbashir, Matthias John, Atanu Roy, Susan Whoriskey, Kristy M. Wood, Paul Hatala, Jason P. Schrum, Kenechi Ejebe, Jeff Lynn Ellsworth, Justin Guild
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Abstract
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
Claims28
An isolated polynucleotide comprising;
- (a) a first region of linked nucleosides, said first region encoding a polypeptide of interest, said polypeptide of interest selected from the group consisting of SEQ ID NOs 4924-9439;
- (b) a first flanking region located at the 5′ terminus of said first region comprising;
- (i) a 5′ untranslated region (5′UTR);
- and
- (ii) at least one 5′ terminal cap;
- and
- (c) a second flanking region located at the 3′ terminus of said first region comprising;
- (i′) a 3′ untranslated region (3′UTR);
- and
- (ii′) a 3′ tailing sequence of linked nucleosides;
- and
- wherein at least one of said linked nucleosides comprises at least one modification as compared to the chemical structure of an A, G, U or C ribonucleoside and wherein at least one of said 5′UTR or said 3′UTR is not derived from the native untranslated region of said polypeptide of interest.
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Dependencies are inferred from the claim text.