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US 2015/0086603 A1Published application
Dual-targeted drug carriers
AssigneeAbbott Cardiovascular Systems Inc.
InventorsSyed F.A. Hossainy, Dariush Davalian, Jinping Wan, Hong Ma
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Abstract
The present invention relates to implantable medical devices containing surface-treated, dual-targeted drug carriers for treating vascular diseases.
Claims17
An implantable medical device, comprising:
- a device body having an exposed surface;
- a drug reservoir layer disposed over at least a portion of the exposed surface of the device body;
- a plurality of particles embedded in the drug reservoir layer;
- one or more therapeutic agents encapsulated in the plurality of particles, wherein
- the particles are surface-treated with a first substance capable of enhancing transport of the particles into a lipid-rich atherosclerotic lesion and a second substance capable of enhancing uptake of the particles into macrophages within the lesion.
2 more elements
A method of treating a vascular disease, comprising:
- deploying in the vasculature of a patient in need thereof an implantable medical device, wherein the device comprises:
- a device body having an exposed surface;
- a drug reservoir layer disposed over at least a portion of the exposed surface of the device body;
- a plurality of particles embedded in the drug reservoir layer;
- one or more therapeutic agents encapsulated in the plurality of particles, wherein
- the particles are surface-treated with a first substance capable of enhancing transport of the particles into a lipid-rich atherosclerotic lesion and a second substance capable of enhancing uptake of the particles into macrophages within the lesion.
3 more elements
Dependencies are inferred from the claim text.