Methods for coating bone allografts with periosteum-mimetic tissue engineering scaffolds
AssigneeColorado State University Research Foundation
InventorsMatthew J. Kipper, Nicole P. Ehrhart, Raimundo Romero, Timothy R. Gonzales
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Abstract
Methods of coating bone surfaces and coated bones comprising a coating comprising (a) a porous polysaccharide scaffold and/or a plurality of polysaccharide nanofibers; and (b) a polyelectrolyte multilayer composition, are disclosed. The methods of coating bone surfaces and the coated bones disclosed provide a biomimetic periosteum to compensate for periosteum lost in preparing bone grafts, and the coated bone grafts, including allografts, restore lost osteogenic and osteoinductive qualities and improve clinical outcomes.
Claims26
A coated bone comprising a coating comprising (a) a porous polysaccharide scaffold or a plurality of polysaccharide nanofibers;
- and (b) a polyelectrolyte multilayer composition.
A method of coating a bone surface comprising contacting the bone with (a) a porous scaffold-forming polysaccharide or a plurality of polysaccharide nanofibers and (b) a polyelectrolyte multilayer composition.
A kit comprising (a) a porous scaffold-forming polysaccharide or nanofiber-forming polysaccharide;
- (b) a polyelectrolyte multilayer-forming composition;
- and (c) instructions for coating a bone surface with (a) and (b).
Dependencies are inferred from the claim text.