Anti-mige antibodies that bind to the junction between ch4 and cemx domains
AssigneeAcademia Sinica
InventorsTse Wen Chang, Jiun-Bo Chen, Chien-Jen Lin, Nien-Yi Chen
Life of this patent
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Abstract
Antibodies binding to junction regions between the CH4 and CεmX domains of membrane-bound IgE and uses thereof in treating IgE-mediated diseases such as allergic diseases.
Claims29
An isolated anti-IgE antibody, which binds to an epitope of a membrane-bound IgE (mIgE), wherein the epitope consists of a first portion and a second portion, the first portion being located in the CH4 domain of the mIgE and the second portion being located in the CεmX domain of the mIgE.
An isolated nucleic acid, comprising an nucleotide sequence encoding an antibody heavy chain variable region that comprises:
- (i) a heavy chain variable region (VH) that contains a VH complementarity determining region (CDR) 1 of GYTFTNYNVH (SEQ ID NO:8), a VH CDR2 of GMYPGNDDILYNQNFKD (SEQ ID NO:9), and a VH CDR3 of SGLQGPWFDY (SEQ ID NO:10);
- or
- (ii) a VH CDR1 of GFSLTDYGVN (SEQ ID NO:19), a VH CDR2 of MIWGDGSTDYNSTL (SEQ ID NO:20), and a VH CDR3 of NWFAY (SEQ ID NO:21).
An isolated nucleic acid, comprising an nucleotide sequence encoding an antibody light chain variable region (VL) that contains:
- (i)
- a VL CDR1 of RASDHINNWLA (SEQ ID NO:
- 5),
- a VL CDR2 of SATSLET (SEQ ID NO:
- 6),
- and a VL CDR3 of QQCWITPFT (SEQ ID NO:
- 7);
- or
- (ii)
- a VL CDR1 of SSSVNYMH (SEQ ID NO:
- 22),
- a VL CDR2 of DTSKLAS (SEQ ID NO:
- 23),
- and a VL CDR3 of QQWSSNPW (SEQ ID NO:
- 24).
An immune composition comprising an immunogenic peptide and an adjuvant, wherein the peptide comprises the amino acid sequence of SVNPGLAGGSAQS (SEQ ID NO:11) or an immunogenic epitope therein.
25-28. (canceled)
Dependencies are inferred from the claim text.