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US 2015/0086555 A1Published application
Anti-Hemagglutinin Antibody Compositions and Methods of Use Thereof
OwnerOle Olsen, Christina L. Boozerinventors
Life of this patent
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Abstract
The present invention provides novel human anti-Influenza antibodies and related compositions and methods. These antibodies are used in the prevention, inhibition, neutralization, diagnosis, and treatment of influenza infection.
Claims32
An isolated fully human monoclonal antibody, wherein said monoclonal antibody has the following characteristics:
- a) binds to an influenza A virus;
- b) binds to a cell contacted with influenza A;
- c) binds to an epitope of an influenza A viral protein;
- and
- d) neutralizes influenza A virus infection.
2 more elements
An isolated anti-hemagglutinin (HA) antibody, wherein said antibody comprises a combination of variable heavy chain complementarity determining region 1 (VH CDR1), variable heavy chain complementarity determining region 2 (VH CDR2), variable heavy chain complementarity determining region 3 (VH CDR3), variable light chain complementarity determining region 1 (VL CDR1), variable light chain complementarity determining region 2 (VL CDR2), and variable light chain complementarity determining region 3 (VL CDR3), selected from the group consisting of:
- (a) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 511;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 512,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 513,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 517;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 181, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 518;
- (b) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 22;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 23,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 24,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 29;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 30, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 31;
- (c) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 34;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 35,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 36,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 41;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 42, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 43;
- (d) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 46;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 47,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 48,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 53;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 54, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 55;
- (e) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 62;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 58,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 59,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 65;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 66, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 67;
- (f) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 70;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 71,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 72,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 77;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 78, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 79;
- (g) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 82;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 83,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 84,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 89;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 90, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 91;
- (h) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 94;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 95,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 96,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 101;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 102, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 103;
- (i) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 106;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 107,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 108,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 113;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 114, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 115;
- (j) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 118;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 119,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 120,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 125;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 126, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 127;
- (k) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 130;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 131,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 132,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 137;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 138, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 139;
- (l) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 142;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 143,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 144,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 149;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 150, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 151;
- (m) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 154;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 155,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 156,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 53;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 54, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 55;
- (n) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 162;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 163,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 164,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 169;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 170, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 171;
- (o) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 174;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 175,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 176,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 157;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 181, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 182;
- (p) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 185;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 186,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 187,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 192;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 30, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 193;
- (q) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 196;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 197,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 198,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 203;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 204, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 205;
- (r) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 208;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 209,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 210,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 215;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 216, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 217;
- (s) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 220;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 221,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 222,
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 227;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 228, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 229;
- (t) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 232;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 233,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 234;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 239;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 240, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 241;
- (u) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 244;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 245,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 246;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 251;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 252, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 253;
- (v) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 256;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 257,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 258;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 263;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 264, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 265;
- (w) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 268;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 269,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 270;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 275;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 276, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 277;
- (x) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 280;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 281,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 282;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 287;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 288, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 289;
- (y) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 292;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 293,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 294;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 299;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 181, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 300;
- (z) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 303;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 304,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 305;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 310;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 30, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 311;
- (aa) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 314;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 315,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 316;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 321;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 322, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 323;
- (bb) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 303;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 326,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 327;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 332;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 216, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 333;
- (cc) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 336;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 337,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 338;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 343;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 216, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 344;
- (dd) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 347;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 348,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 349;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 354;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 355, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 356;
- (ee) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 359;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 360,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 361;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 366;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 367, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 368;
- (ff) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 371;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 372,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 373;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 378;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 379, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 380;
- (gg) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 383;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 384,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 385;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 203;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 181, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 390;
- (hh) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 393;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 394,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 395;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 400;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 216, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 401;
- (ii) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 62;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 58,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 59;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 406;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 66, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 67;
- (jj) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 409;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 410,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 411;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 416;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 417, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 418;
- (kk) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 421;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 422,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 423;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 428;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 429, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 430;
- (ll) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 174;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 175,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 176;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 125;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 126, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 127;
- (mm) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 435;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 436,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 437;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 442;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 443, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 444;
- (nn) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 447;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 448,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 449;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 454;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 455, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 456;
- and
- (oo) a VH CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 154;
- a VH CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 155,
- a VH CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 156;
- a VL CDR1 region comprising the amino acid sequence of SEQ ID NO:
- 520;
- a VL CDR2 region comprising the amino acid sequence of SEQ ID NO:
- 521, and
- a VL CDR3 region comprising the amino acid sequence of SEQ ID NO:
- 522.
490 more elements
An isolated fully human monoclonal anti-hemagglutinin (HA) antibody comprising:
- a) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 510 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 524 or
- b) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 21 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 28 or
- c) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 33 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 40 or
- d) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 45 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 52 or
- e) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 57 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 64 or
- f) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 69 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 76 or
- g) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 81 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 88 or
- h) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 93 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 100 or
- i) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 105 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 112 or
- j) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 117 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 124 or
- k) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 129 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 136 or
- l) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 141 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 148 or
- m) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 153 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 52 or
- n) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 161 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 168 or
- o) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 173 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 180 or
- p) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 184 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 191 or
- q) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 195 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 202 or
- r) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 207 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 214 or
- s) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 219 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 226 or
- t) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 231 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 238 or
- u) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 243 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 250 or
- v) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 255 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 262 or
- w) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 267 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 274 or
- x) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 279 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 286 or
- y) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 291 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 298 or
- z) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 302 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 309 or
- aa) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 313 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 320 or
- bb) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 325 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 331 or
- cc) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 335 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 342 or
- dd) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 346 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 353 or
- ee) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 358 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 365 or
- ff) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 370 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 377 or
- gg) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 382 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 389 or
- hh) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 392 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 399 or
- ii) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 403 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 405 or
- jj) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 420 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 427 or
- kk) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 173 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 124 or
- ll) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 434 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 441 or
- mm) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 446 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 453 or
- nn) a heavy chain variable sequence comprising the amino acid sequence of SEQ ID NO:
- 153 and a light chain variable sequence comprising amino acid sequence SEQ ID NO:
- 519.
117 more elements
Dependencies are inferred from the claim text.